| 2025-12-14 19:00:0714/12/2025 |   New England Patriots vs Buffalo Bills | - | NFL | 2025 | |
| 2025-12-07 19:00:1107/12/2025 |  Bengals vs Buffalo Bills | - | NFL | 2025 | |
| 2025-11-30 22:25:1730/11/2025 |  Buffalo Bills vs Steelers | 26 - 7 | NFL | 2025 | |
| 2025-11-21 02:25:1521/11/2025 |  Buffalo Bills vs Texans | 19 - 23 | NFL | 2025 | |
| 2025-11-16 19:00:2816/11/2025 |  Tampa Bay Buccaneers vs Buffalo Bills | 32 - 44 | NFL | 2025 | |
| 2025-11-09 19:00:2509/11/2025 |  Dolphins vs Buffalo Bills | 30 - 13 | NFL | 2025 | |
| 2025-11-02 22:25:0602/11/2025 |  Buffalo Bills vs Chiefs | 28 - 21 | NFL | 2025 | |
| 2025-10-26 18:00:5026/10/2025 |  Carolina Panthers vs Buffalo Bills | 9 - 40 | NFL | 2025 | |
| 2025-10-14 01:15:4014/10/2025 |  Atlanta Falcons vs Buffalo Bills | 24 - 14 | NFL | 2025 | |
| 2025-10-06 02:20:1806/10/2025 | New England Patriots vs Buffalo Bills | 23 - 20 | NFL | 2025 | |
| 2025-09-28 19:00:5828/09/2025 |  Saints vs Buffalo Bills | 19 - 31 | NFL | 2025 | |
| 2025-09-28 19:00:4828/09/2025 | Saints vs Buffalo Bills | - | NFL | 2025 | |
| 2025-09-19 02:15:2019/09/2025 | Dolphins vs Buffalo Bills | 21 - 31 | NFL | 2025 | |
| 2025-09-14 19:00:1414/09/2025 |  Buffalo Bills vs New York Jets | 30 - 10 | NFL | 2025 | |
| 2025-09-07 02:20:3207/09/2025 |  Ravens vs Buffalo Bills | 40 - 41 | NFL | 2025 | |
| 2025-04-09 11:53:4009/04/2025 |  Cardinals — Buffalo Bills | - | | | |
| 2024-10-08 16:51:1608/10/2024 | Buffalo Bills — Texans | 20 - 23 | NFL | | |
| 2024-10-08 16:50:4408/10/2024 | Buffalo Bills — Ravens | 10 - 35 | NFL | | |
| 2024-10-08 16:49:5608/10/2024 |  Jacksonville Jaguars — Buffalo Bills | 10 - 47 | NFL | | |
| 2024-09-12 02:05:2312/09/2024 | Buffalo Bills — Dolphins | 31 - 10 | NFL | | |
| 2024-09-08 19:00:0308/09/2024 | Cardinals — Buffalo Bills | 28 - 34 | NFL | | |
| 2024-01-14 19:00:3014/01/2024 | Steelers — Buffalo Bills | - | NFL | | |
| 2024-01-06 19:00:0006/01/2024 | Miami Dolphins — Buffalo Bills | 14 - 21 | NFL | | |
| 2023-12-31 19:00:0031/12/2023 | Buffalo Bills — New England Patriots | 27 - 21 | NFL | | |
| 2023-12-24 02:00:0024/12/2023 |  Los Angeles Chargers — Buffalo Bills | 22 - 24 | NFL | | |
| 2023-12-17 22:25:0017/12/2023 |  Buffalo Bills — Dallas Cowboys | 31 - 10 | NFL | | |
| 2023-12-10 22:25:0010/12/2023 | Kansas City Chiefs — Buffalo Bills | 17 - 20 | NFL | | |
| 2023-11-26 22:25:0026/11/2023 |  Philadelphia Eagles — Buffalo Bills | 37 - 34 | NFL | | |
| 2023-11-19 22:25:0019/11/2023 | Buffalo Bills — New York Jets | 32 - 6 | NFL | | |
| 2023-11-14 02:15:0014/11/2023 |  Buffalo Bills — Denver Broncos | 22 - 24 | NFL | | |
| 2023-11-06 02:20:0006/11/2023 | Cincinnati Bengals — Buffalo Bills | 24 - 18 | NFL | | |
| 2023-10-27 02:15:0027/10/2023 | Buffalo Bills — Tampa Bay Buccaneers | 24 - 18 | NFL | | |
| 2023-10-22 19:00:0022/10/2023 | New England Patriots — Buffalo Bills | 29 - 25 | NFL | | |
| 2023-10-16 02:20:0016/10/2023 |  Buffalo Bills — New York Giants | 14 - 9 | NFL | | |
| 2023-10-08 15:30:0008/10/2023 | Buffalo Bills — Jacksonville Jaguars | 20 - 25 | NFL | | |
| 2023-10-01 19:00:0001/10/2023 | Buffalo Bills — Miami Dolphins | 48 - 20 | NFL | | |
| 2023-09-17 19:00:0017/09/2023 |  Buffalo Bills — Las Vegas Raiders | 38 - 10 | NFL | | |
| 2023-09-12 02:15:0012/09/2023 | New York Jets — Buffalo Bills | 22 - 16 | NFL | | |
| 2023-01-22 19:00:3522/01/2023 | Buffalo Bills — Bengals | 10 - 27 | NFL | | |
| 2023-01-15 19:00:2015/01/2023 | Buffalo Bills — Dolphins | 34 - 31 | NFL | | |
| 2023-01-08 19:00:5808/01/2023 | week18 | 35 - 23 | NFL | | |
| 2023-01-02 11:22:0902/01/2023 | week17 | S - S | NFL | | |
| 2022-12-24 11:21:2224/12/2022 |  week16 | 13 - 35 | NFL | | |
| 2022-12-18 11:20:4018/12/2022 | Buffalo Bills — Dolphins | 32 - 29 | NFL | | |
| 2022-12-11 11:19:3611/12/2022 | week14 | 20 - 12 | NFL | | |
| 2022-12-01 11:17:5201/12/2022 | week13 | 10 - 24 | NFL | | |
| 2022-11-24 11:15:1024/11/2022 |  week12 | 25 - 28 | NFL | | |
| 2022-11-20 11:12:0620/11/2022 |  week11 | 31 - 23 | NFL | | |
| 2022-11-13 19:00:3913/11/2022 |  week10 | 30 - 33 | NFL | | |
| 2022-11-06 19:00:2206/11/2022 | week9 | 20 - 17 | NFL | | |
| 2022-10-31 01:20:2031/10/2022 |  week 8 | 27 - 12 | NFL | | |
| 2022-10-16 18:14:0816/10/2022 | Week 6 | 20 - 24 | NFL | | |
| 2022-10-09 19:00:4009/10/2022 | Week 5 | 38 - 3 | NFL | | |
| 2022-10-02 14:30:4702/10/2022 | week 4 | 20 - 23 | NFL | | |
| 2022-09-25 18:00:5625/09/2022 | Week 3 | 21 - 19 | | | |
| 2022-09-19 14:38:0619/09/2022 |  Week 2 | 41 - 7 | NFL | | |
| 2022-09-09 19:00:2609/09/2022 |  Week 1 | 10 - 31 | | | |
